emm5.46 (emm-cluster M5) subtype-determining sequence encoding signal sequence C terminal 10 residues and N terminal 50 residues of mature M protein. emm5.46 from GAS necrotizing fasciitis (lower arm) isolate A1040400122 recovered from 81 year old Dutch male during 2004. speC positive.Sequence Xand information provided by Dr. Xander Huijsdens, National Institute for Public Health and the Environment, Bilthoven Netherlands. . . . emm5.46.sds Length: 180 August 30, 2006 16:18 Type: N Check: 2351 .. 1 TTAGTTGTCA ATACTAATGA AGTTAGTGCA ACCGTGACTA GGGGTACAAT 51 AAATGACCCG CAAAGAGCAA AAGAAACTCT TGACAAGTAT GAGCTAGAAA 101 ACCATGAGTT AAAAACTAAG AATGAAGGGT TAAAAACTGA GAATGAAGGG 151 TTAAAAACTG AGAATGAAGG GTTAAAAACT